Unintended effects of statins from observational studies in the general population: sys... - 0 views
www.ncbi.nlm.nih.gov/...PMC3998050
statin therapy statins myopathy cholesterol side effects diabetes liver liver enzymes
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A markedly increased risk of myopathy was observed
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One cohort study (Women’s Health Initiative) of higher quality and larger sample size found stronger evidence of an increased risk of self-reported T2DM (OR=1.47; 95% CI 1.32 to 1.64) for the groups of women who reported statin use at baseline and three years later
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Smeeth et al. found an increased risk of incident liver disease in the first year after the index date
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The cumulative incidence of T2DM after three years of statin treatment was 6.25%, corresponding to an excess risk of 2.25%
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We found no increased risk of peripheral neuropathy, depression, common eye diseases, renal disorders or arthritis associated with taking statins. Studies of higher quality did not show previously reported protective effects of statins on fractures, venous thrombo-embolism or pneumonia
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Statin use associated with increased myopathy, liver dysfunction, and type II Diabetes. The authors conclude that the absolute risk is very low, yet OR was 1.47 for type II Diabetes (translated 47% increased odds of developing Diabetes as a result of statins) and OR of 2.63 in risk of myopathy (translated 163% increased odds of developing myopathy as a result of statins). Seems the authors "low risk" statement is just applies to those without symptoms/side effects. Physicians need to do a better job of understanding risks and customizing therapies.